Monday, 12th February 39th Annual Lorne Genome Conference 2018
Breakfast Workshop - Implementing CRISPR CAS9
7:30AM - 8:30AM
Monday, 12th February
Auditorium
Chair: Paul Thomas
Micro Break
8:30AM - 8:40AM
Monday, 12th February
Auditorium Foyer
Session 2: Computational Biology
8:40AM - 10:10AM
Monday, 12th February
Auditorium
Chairs: Alicia Oshlack & Gaetan Burgio
Sponsored by:
Morning Tea
10:10AM - 11:00AM
Monday, 12th February
Exhibition Hall
Session 3: Gene Regulation
11:00AM - 12:30PM
Monday, 12th February
Auditorium
Chairs: Alistair Forrest & Leonie Quinn
Sponsored by:
- Single-cell tumor transcriptomics: algorithms and applications - Shyam Prabhakar
- Transcriptional regulation of neuronal function by the histone demethylase KDM5 - Julie Secombe
- Chromatin modifiers SET-32 and SET-25 establish a transgenerational silencing signal in Caenorhabditis elegans - Rachel Woodhouse
- DNA replication timing shapes the cancer epigenome - Qian Du
Lunch
12:30PM - 1:15PM
Monday, 12th February
Exhibition Hall
Afternoon Break/High-content functional genomics workshop
1:15PM - 2:45PM
Monday, 12th February
Horizons Room
Chair: Kaylene Simpson
Micro Break
2:45PM - 3:00PM
Monday, 12th February
Auditorium Foyer
Session 4A: Regulation of Gene Expression
3:00PM - 4:00PM
Monday, 12th February
Auditorium
Chairs: Alyson Ashe & Greg Neely
- 3’-deoxyadenosine induces bulk transcript lengthening via alternative polyadenylation - Belinda J Goldie
- Intron retention: A widespread and conserved mechanism of gene expression control regulated by epigenetic changes - Justin JL Wong
- Understanding the role of eosinophils in adipose tissue energy expenditure - Kate GR Quinlan
- Modelling breast cancer progression using massively-parallel single-cell RNAseq technology. - David Gallego Ortega
Session 4B: Disease & Development
3:00PM - 4:00PM
Monday, 12th February
Horizons Room
Chairs: Andrew Perkins & Julia Horsfield
- Genome sequencing of 15,000 healthy elderly Australians - Paul Lacaze
- Identifying the cause and function of T>G mutations in oesophagus and gastric cancer genomes - Jayne A Barbour
- Cardiac directed differentiation using small molecule Wnt modulation at single-cell resolution - Nathan Palpant
- Essential roles for minor class splicing in development and cancer - Karen Doggett
Mini Break
4:00PM - 4:30PM
Monday, 12th February
Auditorium Foyer
Session 5: Julian Wells Medal/Noncoding RNA and RNA Regulation
4:30PM - 6:30PM
Monday, 12th February
Auditorium
Chairs: Vincent Harley & Timothy Mercer
Sponsored by:
- MicroRNAs act on and within regulatory networks - Greg Goodall
- Coordination of RNA Processing events in vivo - Karla Neugebauer
- Enhancing the spatiotemporal sub-nuclear sequestration of RNA binding proteins by manipulating paraspeckle size - Archa Fox
- Elevated foetal globin caused by natural regulatory mutations that disrupt foetal repressor binding - Gabriella E Martyn
- Cross-regulation between the ethylene and abscisic acid hormone signalling pathways is regulated by EDF transcription factors - Mathew G. Lewsey
- RNA-dependent epigenetic silencing directs transcriptional down regulation caused by intronic repeat expansions - Sureshkumar Balasubramanian
- Duplication and deletion of key SOX9 enhancers causes sex reversal in humans - Brittany Croft
- Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids - Ewa M Michalak
- Welcome to the macrogenomics era: a long read revolution - Martin Smith
Dinner Break
6:30PM - 8:30PM
Monday, 12th February
Poster Session 2
8:30PM - 10:30PM
Monday, 12th February
Louttit Bay Room
- Molecular and cellular role of RNA-binding proteins in cardiac biology and disease - Lithin Louis
- FANCM protects telomeres from aberrant replication fork processing in cancers engaging in Alternative Lengthening of Telomeres (ALT) - Robert Lu
- Investigating the role of ZBTB7A homodimerisation in adult erythroid cells - Lana C Ly
- KLF1 is a pioneer transcription factor for erythroid cells - Graham W Magor
- Restoring Central Inhibition Relieves Chronic Neuropathic Pain - John Manion
- When is a global repressor not a repressor? Genome-wide profiling of the Snail family transcription factor Worniu in neural stem cells - Owen J Marshall
- Modelling transcriptional variability in single cell RNA-seq data during human embryogenesis captures changes in the regulation of critical developmental genes - Elizabeth A Mason
- Coordinated up-regulation of splicing machinery components in a zebrafish intestinal development mutant harbouring a mutation in gtf2h4, a component of the general transcription factor complex, TFIIH - Stephen Mieruszynski
- Identification of Hippo pathway target genes important for tissue growth. - Katrina A Mitchell
- Genetic and chemical approaches to inhibiting hyperplasia in a zebrafish model of hepatocellular carcinoma - Kimberly Morgan
- NEAT1 changes imatinib response and contributes to tyrosine kinase inhibitor-based resistance in a chronic myleoid leukemia cell line - Zeynep MUTLU
- Whole genome dissection of the box jellyfish venom death pathway - Greg Neely
- Topoisomerase 2A is essential for maintenance of mitotic chromosome structure - Christian Friberg F Nielsen
- Investigating the evolution of truffle-like fungi - Andy R Nilsen
- Mutational Landscape of Familial Breast Cancers - Katia Nones
- Single-cell RNA profiling reveals developmental lineage relationships between the mouse mammary epithelial cells - Bhupinder Pal
- Genomics of malignant pleural mesothelioma - Ann-Marie Patch
- Human SRY regulates haploid specific Protamine (PRM1) promoter activity - Deepali Pathak
- Predicting the outcome of breast cancer using novel RNA-Seq analysis - Andrew Pattison
- Computational modeling reveals 4D genome reorganization during stem cell differentiation - Jonas Paulsen
- A Functional Genomic Approach to Identifying New Motor Neuron Disease Genes and Drug Targets - Jodie Pearlman
- A general framework for evaluating cross-platform concordance in genomic studies - Timothy J Peters
- Developing CRISPR-Cas9 Based Gene Drives in Mus musculus - Chandran Pfitzner
- Insights into the biogenesis and possible functions of exonic circular RNA - Chikako Ragan
- The identification of rare variants in Tasmanian prostate cancer pedigrees using whole-genome sequencing - Kelsie Raspin
- Splicing factors as novel regulators of oncogenic miRNAs - Madara Ratnadiwakara
- Expanding the RNA-guided endonuclease toolkit for mouse genome editing. - Louise Robertson
- The A/HeJ Mouse: Dysfunction in Sex Development - Jessica Robinson
- MASTL overexpression promotes chromosome instability and metastasis in breast cancer - Samuel Rogers
- Overcoming off target effects in CRISPR and RNAi loss of function screens - Joseph Rosenbluh
- Characterising Human Variants of the Transcription Factors NPAS3 and NPAS4 Identified in Patients with Mental Illness - Joseph J Rossi
- Modulation of higher order chromatin structures associated with virus-specific killer T cell differentiation - Brendan Russ
- Highly Parallel Concurrent Gene Expression and Iso-Seq Analysis of Single Cells - Jafar S. Jabbari
- DECENT: Differential Expression with Capture Efficiency adjustmeNT for Single-Cell RNA-seq Data - Agus Salim
- Comparative phylogenomic evidence for a novel detoxification gene family in insects - Jack Scanlan
- Breaking point: computational interrogation of structural variation in cancer - Colin A Semple
- Investigating the role of R-loops in erythroid differentiation - Manan Shah
- Developing a bioinformatics pipeline to measure changes in ribosomal RNA genes copy number in cancer - Diksha Sharma
- In vivo targets and mechanisms of gene control during protein synthesis - Nikolay Shirokikh
- Targeting telomeric repeat-binding factor 2 (TRF2) with small molecule inhibitors to prevent cancer cell growth - Alexander P. Sobinoff
- Gene editing of the multi-copy H2A.B.3 gene family by a single pair of TALENs - Tanya Soboleva
- Investigating the role of MYD88 mutations in lymphoma. - Huma Sohail
- BET bromodomain inhibition sensitises ribosomal DNA to localised damage and provides a robust synergistic therapeutic strategy for treating AML - Jirawas Sornkom
- Nuclear microRNAs as Direct Regulators of Transcription - Laura Sourdin
- The Search for Disease Severity Modifiers in Patients Suffering from Blood Disorders - Elizabeth S Stout
- Invasive Lobular Breast Cancer: Using tumour genome-wide DNA methylation to further subtype and aid in the identification of susceptibility genes. - Medha Suman
- Integrated profiling of single-cell chromatin accessibility and transcriptome reveals regulatory heterogeneity - Stephanie Sun
- Exploring the combinatorial effects of epigenetic modifiers upon the mammalian genome using CRISPR-dCas9 - Tessa Swain
- Identifying Novel Testis-Determining Genes from Integrated RNAseq and ChIPseq Data - Aleisha Symon
- Investigating the role of Cis and Trans acting regulators in the process of X inactivation - Andres ATdF Tapia del Fierro
- Investigating DNA transposition as a cause of genomic instability and therapy-resistance in Chronic Myeloid Leukaemia - Daniel Thomson
- Bayesian neural network based modelling of steady-state splicing mechanism. - KANUPRIYA TIWARI
- Repetitive RNA and genomic instability in high-grade serous ovarian cancer progression and development - James R Torpy
- Investigation into the mechanisms of alternative 3’UTRs in the control of gene expression - Rachael E Turner
- Pre-miRNA Folding Through Context-Free Grammar Parsing and the Identification of miRNA Using a Feedforward Neural Network - Sonika Tyagi
- Click chemistry enables preclinical evaluation of targeted epigenetic therapies - Dean S. Tyler
- Characterization of COL3A1 mutations causing Ehler-Danlos Syndrome type IV: the first step in designing molecular therapies - Sasiwimon Utama
- shRNA screen for novel epigenetic regulations of y-globin silencing - Jim Vadolas
- Novel contribution of acetylated histone variant H2A.Z in activation of neo-enhancers in prostate cancer. - Fatima Valdes Mora
- Transcriptional characterization of low input frozen brain samples at single-nucleus resolution using 10x Genomics Chromium microfluidics - Dulce Vargas Landin
- Racing against the (epigenetic) clock: physical activity reverses age-related epigenetic drift in human skeletal muscle - Sarah Voisin
- Dissecting the roles of eIF2 and eIF3 during translation using TCP-seq - Susan Wagner
- Molecular Dynamics Modelling of a Variant of Unknown Effect in RAD51D - Matthew Wakefield
- Development and optimization of an efficient method for CRISPR/Cas correction of patient-specific iPSCs - Qi Wang
- An optimal approach to assembling chloroplast genome - Weiwen wang
- Characterizing the epigenetic modifier Smchd1 in X chromosome inactivation - Iromi Wanigasuriya
- NxtIRF: A novel computational approach to measure differential intron retention in cancer databases - Alex CH Wong
- Roles of histone variant H3.3 and ATRX in tumourigenesis - Lee Wong
- Systematic discovery of coding and noncoding transcriptomic variants in liver cancer - Hyun Goo Woo
- DNA methylation and transcription factor binding - Lu Yang
- ZNF827 - a molecular target for telomere maintenance in cancer - Sile Fiona Yang
- Identification and characterization of novel cell populations using single-cell RNA-seq: an example on breast cancer T cell infiltrate - Chengzhong Ye
- The FUBP1 Drosophila ortholog Psi interacts with the Mediator Complex to regulate growth through modulating expression of MYC and RNA processing machinery - Olga Zaytseva